References

Clavo B, Catala L, Perez JL, Rodriguez V, Robaina F. Ozone therapy on cerebral blood flow: a preliminary report. Evid Based Complement Alternat Med. 2004; 1:(3)315-319 https://doi.org/10.1093/ecam/neh039

Di Mauro R, Cantarella G, Bernardini R The biochemical and pharmacological properties of ozone: the smell of protection in acute and chronic diseases. Int J Mol Sci. 2019; 20:(3) https://doi.org/10.3390/ijms20030634

Elvis AM, Ekta JS. Ozone therapy: a clinical review. J Nat Sci Biol Med. 2011; 2:(1)66-70 https://doi.org/10.4103/0976-9668.82319

Hernández A, Vinals M, Isidoro T, Vilas F. Potential role of oxygen-ozone therapy in treatment of COVID-19 pneumonia. Am J Case Rep. 2020; 21:e925849-1-e925849-6 https://doi.org/10.12659/AJCR.925849

Juchniewicz H, Lubkowska A. Oxygen-ozone (O2-O3) therapy in peripheral arterial disease (PAD): a review study. Ther Clin Risk Manag. 2020; 16:579-594 https://doi.org/10.2147/TCRM.S255247

Marini S, Maggiorotti M, Dardes N Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study. J Biol Regul Homeost Agents. 2020; 34:(3) https://doi.org/10.23812/20-250-E-56

Swanson T, Chapman J. Ozone toxicity.Treasure Island (FL): Statpearls Publishing; 2020

Wu X, Li Z, Liu X Major ozonated autothemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction. Neural Regen Res. 2013; 8:(5)461-468 https://doi.org/10.3969/j.issn.1673-5374.2013.05.010

A look at the potential uses of oxygen-ozone therapy

02 November 2020
Volume 25 · Issue 11

Ozone (O3) therapy has been studied for more than a century and has been well established as an effective method to disinfect surfaces and liquids treat disease (Juchniewicz and Lubkowska, 2020). O3 therapy, sometimes referred to as oxygen-ozone therapy involves the administration of a mixture of oxygen and ozone (Alberto-Hernández et al, 2020). While ozone is a molecule consisting of three oxygen atoms, two of these three make up a stable pair (O2), which is accompanied by a third unstable atom, which gives the therapy its beneficial effects (Alberto-Hernández et al, 2020).

Despite O3 therapy having been around for more than 150 years, more than a century of study and evidence of its benefits, opinions are still divided over its use (Juchniewicz and Lubkowska, 2020). The reason for this may well be the potential toxicity of O3 (Juchniewicz and Lubkowska, 2020) and controversial study findings regarding its safety and efficacy (Di Mauro et al, 2019).

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