References

Abdelhafiz AH, Sinclair AJ. Cognitive frailty in older people with type 2 diabetes mellitus: the central role of hypoglycaemia and the need for prevention. Curr Diab Rep. 2019; 19:(4) https://doi.org/10.1007/s11892-019-1135-4

Almutairi JS, Almigbal TH, Alruhaim HY Self-awareness of HbA1c and its association with glycemic control among patients with type 2 diabetes: A multicenter study. Saudi Med J. 2022; 43:(3)291-300 https://doi.org/10.15537/smj.2022.43.3.20210536

Bu Z, Huang A, Xue M, Li Q, Bai Y, Xu G. Cognitive frailty as a predictor of adverse outcomes among older adults: A systematic review and meta-analysis. Brain Behav. 2021; 11:(1) https://doi.org/10.1002/brb3.1926

Chaput JP, Dutil C, Featherstone R Sleep timing, sleep consistency, and health in adults: a systematic review. Appl Physiol Nutr Metab. 2020; 45:(10)S232-S247 https://doi.org/10.1139/apnm-2020-0032

Creavin ST, Wisniewski S, Noel-Storr AH Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016; 2016:(1) https://doi.org/10.1002/14651858.cd011145.pub2

Diabetes UK. How many people in the UK have diabetes?. 2023. https//www.diabetes.org.uk/professionals/position-statements-reports/statistics (accessed 23 October 2023)

Dove A, Shang Y, Xu W, Grande G, Laukka EJ, Fratiglioni L, Marseglia A. The impact of diabetes on cognitive impairment and its progression to dementia. Alzheimers Dement. 2021; 17:(11)1769-1778 https://doi.org/10.1002/alz.12482

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56:(3)M146-56 https://doi.org/10.1093/gerona/56.3.m146

Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants. Lancet Public Health. 2018; 3:(7)e323-e332 https://doi.org/10.1016/s2468-2667(18)30091-4

Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, Baker P, Smith E, Buchbinder R. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012; 65:(9)934-939

Hurtado MD, Vella A. What is type 2 diabetes?. Medicine. 2019; 47:(1)10-15 https://doi.org/10.1016/j.jclinepi.2011.11.014

Ibáñez V, Silva J, Cauli O. A survey on sleep questionnaires and diaries. Sleep Med. 2018; 42:90-96 https://doi.org/10.1016/j.sleep.2017.08.026

Joanna Briggs Institute. Checklist for systematic reviews and research syntheses. 2017. https//jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Systematic_Reviews2017_0.pdf (accessed 23 October 2023)

Koh DH, Rho YJ, Lee SY, Kim KN, Ju YJ. Association between blood glucose control and subjective cognitive decline in korean patients with diabetes aged over 50 years. Int J Environ Res Public Health. 2022; 19:(12) https://doi.org/10.3390/ijerph19127267

Levis B, Benedetti A, Thombs BD Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019; 365 https://doi.org/10.1136/bmj.l1476

Luchsinger JA, Ryan C, Launer LJ. Diabetes and cognitive impairment, 3rd edn. In: Cowie CC, Casagrande SS, Menke A (eds). Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2018

Lyu Q, Guan CX, Kong LN, Zhu JL. Prevalence and risk factors of cognitive frailty in community-dwelling older adults with diabetes: A systematic review and meta-analysis. Diabet Med. 2023; 40:(1) https://doi.org/10.1111/dme.14935

National Institute for Health and Care Excellence. Mental wellbeing in over 65s: occupational therapy and physical activity interventions: Public health guideline [PH16]. 2008. https//www.nice.org.uk/guidance/ph16/chapter/1-Recommendations (accessed 23 October 2023)

National Institute for Health and Care Excellence. Type 2 diabetes in adults: management. 2022. https//www.nice.org.uk/guidance/ng28/chapter/Recommendations#blood-glucose-management (accessed 23 October 2023)

O'Donovan M, Sezgin D, O'Caoimh R, Liew A. The relationship between frailty and diabetes: An investigation of self-rated health, depression symptoms and quality of life in the Study of Health Aging and Retirement in Europe. Arch Gerontol Geriatr. 2021; 96 https://doi.org/10.1016/j.archger.2021.104448

Randhi B, Gutlapalli SD, Pu J Sleep disorders in mild cognitive impairment. Cureus. 2023; 15:(3) https://doi.org/10.7759%2Fcureus.36202

Rockwood K, Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can Geriatr J. 2020; 23:(3)210-215 https://doi.org/10.5770/cgj.23.463

Rossi PG, Carnavale BF, Farche ACS, Ansai JH, de Andrade LP, Takahashi ACM. Effects of physical exercise on the cognition of older adults with frailty syndrome: A systematic review and meta-analysis of randomized trials. Arch Gerontol Geriatr. 2021; 93 https://doi.org/10.1016/j.archger.2020.104322

Shin C, Park MH, Lee SH, Ko YH, Kim YK, Han KM, Jeong HG, Han C. Usefulness of the 15-item geriatric depression scale (GDS-15) for classifying minor and major depressive disorders among community-dwelling elders. J Affect Disord. 2019; 259:370-375 https://doi.org/10.1016/j.jad.2019.08.053

Sugimoto T, Arai H, Sakurai T. An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions. Geriatr Gerontol Int. 2022; 22:(2)99-109 https://doi.org/10.1111/ggi.14322

Thompson MQ, Theou O, Tucker GR, Adams RJ, Visvanathan R. FRAIL scale: Predictive validity and diagnostic test accuracy. Australas J Ageing. 2020; 39:(4)e529-e536 https://doi.org/10.1111/ajag.12829

Introduction to frailty. Fit for frailty part 1. 2014. https//www.bgs.org.uk/resources/introduction-to-frailty (accessed 23 October 2023)

Wei YC, Chen CK, Lin C, Chen PY, Hsu PC, Lin CP, Shyu YC, Huang WY. Normative data of mini-mental state examination, Montreal cognitive assessment, and Alzheimer's disease assessment scale-cognitive subscale of community-dwelling older adults in Taiwan. Dement Geriatr Cogn Disord. 2022; 51:(4)365-376 https://doi.org/10.1159/000525615

Woo J, Leung J, Morley JE. Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation. J Am Geriatr Soc. 2012; 60:(8)1478-1486 https://doi.org/10.1111/j.1532-5415.2012.04074.x

World Health Organization. Global recommendations on physical activity for health. 2010. https//www.who.int/publications/i/item/9789241599979 (accessed 23 October 2023)

Yoshiura K, Fukuhara R, Ishikawa T Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD). Sci Rep. 2022; 12:(1) https://doi.org/10.1038/s41598-022-12195-4

Zhao W, Hu P, Sun W, Wu W, Zhang J, Deng H, Huang J, Ukawa S, Lu J, Tamakoshi A, Liu X. Effect of physical activity on the risk of frailty: A systematic review and meta-analysis. PLoS One. 2022; 17:(12) https://doi.org/10.1371/journal.pone.0278226

Cognitive frailty in older adults with diabetes: prevalence and risk factors

02 November 2023
Volume 28 · Issue 11

Abstract

In older adults living with diabetes, there is a higher prevalence of frailty and a greater risk of cognitive impairment. Cognitive frailty is defined by the presence of both and is associated with an increased risk of mortality. A systematic review was undertaken to estimate the prevalence of cognitive frailty in community-dwelling older adults living with diabetes and associated risk factors. This commentary critically appraises the review and explores the implications of the findings for community practice.

In the UK, 4.3 million people live with diabetes, while a further 850 000 could be living with the condition and be unaware of it (Diabetes UK, 2023). Type 2 diabetes mellitus is a chronic metabolic disorder, characterised by hyperglycaemia, and is associated with greater risks of heart disease, stroke, peripheral neuropathy, renal disease, blindness and amputation (Hurtado and Vella, 2019). Middle-aged and older adults with diabetes have a higher prevalence of frailty (Hanlon et al, 2018), an increased vulnerability associated with ageing, and experience a decline in the body's physical and psychological reserves (Turner, 2014). Both diabetes and frailty are independently associated with low self-rated health, depressive symptoms and low quality of life (O'Donovan et al, 2021).

In addition to physical frailty, cognitive impairment is increasingly recognised as a potential complication of diabetes, which may reflect a direct effect on the brain of hyperglycaemia or the effects of associated comorbidities such as hypertension (Luchsinger et al, 2018). Diabetes that is poorly controlled in older adults is also associated with double the risk of cognitive impairment no dementia (CIND) and triple the risk of CIND progressing to dementia (Dove et al, 2021).

Register now to continue reading

Thank you for visiting Community Nursing and reading some of our peer-reviewed resources for district and community nurses. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Limited access to clinical or professional articles

  • New content and clinical newsletter updates each month